Hereditary Deficiency of gp91 phox Is Associated With Enhanced Arterial Dilatation
نویسندگان
چکیده
منابع مشابه
Hereditary deficiency of gp91(phox) is associated with enhanced arterial dilatation: results of a multicenter study.
BACKGROUND NADPH oxidase is believed to modulate arterial tone, but its role in humans is still unclear. The objective of this study was to evaluate whether NADPH oxidase is involved in flow-mediated arterial dilation (FMD). METHODS AND RESULTS Twenty-five patients with hereditary deficiency of gp91(phox), the catalytic core of NADPH oxidase, (X-CGD), 25 healthy subjects, and 25 obese patient...
متن کاملHereditary Deficiency of gp91 Is Associated With Enhanced Arterial Dilatation Results of a Multicenter Study
Background—NADPH oxidase is believed to modulate arterial tone, but its role in humans is still unclear. The objective of this study was to evaluate whether NADPH oxidase is involved in flow-mediated arterial dilation (FMD). Methods and Results—Twenty-five patients with hereditary deficiency of gp91, the catalytic core of NADPH oxidase, (X-CGD), 25 healthy subjects, and 25 obese patients matche...
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Formation of reactive oxygen metabolites is vital for the microbicidal activity of phagocytes. As an unwanted side effect, these metabolites may contribute to oxidative stress in the vasculature and thus lead to arteriosclerosis. p22 phox, a component of the NADH/NADPH oxidase in phagocytes and vascular smooth muscle cells, is essential for production of reactive oxygen metabolites. Recently, a...
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ژورنال
عنوان ژورنال: Circulation
سال: 2009
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.109.877191